Allogeneic Stem-Cell Transplant for Intermediate Risk AML Patients
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/ Published Apr 3, 2020

Allogeneic Stem-Cell Transplant for Intermediate Risk AML Patients

Medical Source: Dr. George Yaghmour
Keck School of Medicine - USC
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Is a Stem-Cell Transplant Needed?

  • AML patients who are considered “intermediate risk”  may need allogeneic stem-cell transplant, but in all cases
  • Whether the transplant is given depends on how well the patient responds to standard chemotherapy as well as how much disease is still detectable in your body
People with acute myeloid leukemia (AML) who are considered intermediate risk may be given the option to undergo a allogeneic stem-cell transplant, says Dr. George Yaghmour, an Assistant Professor of Clinical Medicine at USC's Keck School of Medicine. In this procedure, healthy stem cells are put into the body to replace your damaged bone marrow.

RELATED: What Should AML Patients Expect During a Bone Marrow Transplant?

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If an “intermediate risk” patient responds well to the standard chemotherapy for AML, they may not need to undergo a transplant, Dr. Yaghmour says. The way your doctor will determine whether to recommend an allogeneic stem-cell transplant depends on something called minimal residual disease.

“This is how we now define remission. If you have minimal residual disease … intermediate risk disease sometimes can be good if you respond to the standard chemotherapy, then you don’t need transplantation — and you have a good outcome,” Dr. Yaghmour says.

Learn more about SurvivorNet's rigorous medical review process.

Dr. George Yaghmour is an Assistant Professor of Clinical Medicine at USC's Keck School of Medicine. Read More

Stem-Cell Transplants for AML

Stem-cell transplants allow for doctors to give high doses of chemotherapy to people with AML, but the side effects can be severe. It’s important for people to be monitored closely for weeks as the immune system regrows.

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