What Causes CLL?
- The exact cause of CLL is unknown.
- Researchers believe it’s caused by some combination of genetic mutation in the DNA of blood-producing cells and exposure to something in the environment, such as chemicals or radiation.
- There are no known ways to prevent CLL, according to the Leukemia & Lymphoma Society.
No one knows exactly what causes chronic lymphocytic leukemia (CLL). According to Dr. Nicole Lamanna, a leukemia specialist and associate professor at Columbia University Medical Center, CLL develops from de novo mutations, or new genetic mutations, that scientists don't yet fully understand.
But researchers do believe it’s caused by some combination of genetic mutation in the DNA of blood-producing cells and exposure to something in the environment, such as chemicals or radiation. It’s a chronic disease that people can live with for years and treatment varies depending on whether the disease grows slowly or is more aggressive.
Read More According to the
Leukemia & Lymphoma Society, for most people there are no obvious reasons why they develop CLL. However, researchers have found a potential association between CLL and exposure to herbicides such as Agent Orange, which was used in the Vietnam War from 1961-1971. Researchers have also found in a small number of cases, first-degree relatives of people with CLL are more likely to develop CLL than people who don’t have first-degree relatives with the disease. According to the
National Comprehensive Cancer Network, family members of someone with CLL are 7-8 times more likely to develop the disease. There are no known ways to prevent CLL, according to LLS.
The importance of genetic testing after a CLL diagnosis
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Dr. Nicole Lamanna is a hematologist/oncologist at Columbia University Medical Center. Her research interests include lymphoid leukemias, specifically chronic lymphocytic leukemia (CLL). Read More