Hypofractionated Radiation Therapy in Preventing Recurrence in Patients With Breast Cancer After Surgery

Inclusion Criteria:

Histological confirmation of breast cancer
Pathologic stage T0-T3N0-N1M0
Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0 to 2
Able to and provides Institutional Review Board (IRB) approved study specific written informed consent
Study entry must be within 12 weeks of last surgery (breast or axilla) or last chemotherapy (if applicable)
Able to complete all mandatory tests
Willing to return to enrolling institution for follow-up (during the active monitoring phase of the study)
Fair, good or excellent cosmesis, as determined by trained nurse assessment using the Harvard Cosmetic Scale
Radiotherapy must begin within 12 weeks of the last breast cancer surgery or the last dose of adjuvant chemotherapy
Breast conserving surgery and indications for whole breast radiotherapy

Exclusion Criteria:

Medical contraindication to receipt of radiotherapy
Severe active co-morbid systemic illnesses or other severe concurrent disease which, in the judgment of the investigator, would make the patient inappropriate for entry into this study or interfere significantly with the proper assessment of safety and toxicity of the prescribed regimens
Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements or providing informed consent
Active systemic lupus or scleroderma
Pregnancy
Prior receipt of ipsilateral breast or chest wall radiation
Positive margins on ink after definitive surgery either for ductal carcinoma in situ (DCIS) or invasive cancer
History of non-breast malignancies (except for in situ cancers treated only by local excision and basal cell and squamous cell carcinomas of the skin) within 5 years prior study entry
Recurrent breast cancer
Indications for comprehensive regional nodal irradiation