Multiple Myeloma Clinical Trial

An Extension Study of Tocilizumab (Myeloma Receptor Antibody [MRA]) in Patients Completing Treatment in Tocilizumab Core Studies

Summary

This single-arm study evaluated the long-term efficacy and safety of tocilizumab in participants who had completed treatment in the tocilizumab core studies (NCT00106522 [Roche protocol WA18062], NCT00106574 [Roche protocol WA18063], and NCT00109408 [Roche protocol WA17824]) of adults with rheumatoid arthritis. Participants received tocilizumab alone or in combination with standard anti-rheumatic treatment.

View Eligibility Criteria

Eligibility Criteria

Inclusion Criteria:

Patients who have completed participation in 1 of the core studies in adult rheumatoid arthritis.

Exclusion Criteria:

Treatment with any investigational agent since the last administration of study drug in the core studies.
Treatment with iv gamma globulin, plasmapheresis, or prosorba column since the last administration of study drug in the core studies.
Treatment with an anti-TNF or anti-IL1 agent, a T-cell co-stimulation modulator, or any biologic since the last administration of study drug in the core studies.
Immunization with a live/attenuated vaccine since the last administration of study drug in the core studies.
Previous treatment with any cell-depleting therapies, including investigational agents.
Parenteral, intramuscular, or intra-articular corticosteroids within 6 weeks prior to baseline in this study.

Study is for people with:

Multiple Myeloma

Phase:

Phase 3

Estimated Enrollment:

2067

Study ID:

NCT00720798

Recruitment Status:

Completed

Sponsor:

Hoffmann-La Roche

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There are 290 Locations for this study

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Birmingham Alabama, 35294, United States

Huntsville Alabama, 35801, United States

Mesa Arizona, 85208, United States

Paradise Valley Arizona, 85253, United States

Peoria Arizona, 85381, United States

Scottsdale Arizona, 85251, United States

Scottsdale Arizona, 85258, United States

Tucson Arizona, 85723, United States

Tucson Arizona, 85724, United States

Little Rock Arkansas, 72205, United States

Anaheim California, 92801, United States

Long Beach California, 90806, United States

Long Beach California, 90808, United States

Los Angeles California, 90045, United States

Los Angeles California, 90095, United States

Palm Desert California, 92260, United States

Palm Springs California, 92262, United States

Palo Alto California, 94304, United States

San Diego California, 92101, United States

San Diego California, 92108, United States

San Jose California, 95126, United States

San Leandro California, 94578, United States

Santa Maria California, 93454, United States

Torrance California, 90505, United States

Upland California, 91786, United States

Colorado Springs Colorado, 80910, United States

Newark Delaware, 19713, United States

Aventura Florida, 33180, United States

Delray Beach Florida, 33484, United States

Fort Lauderdale Florida, 33334, United States

Palm Habor Florida, 34684, United States

Palm Harbor Florida, 34684, United States

Sarasota Florida, 34239, United States

Tampa Florida, 33609, United States

Tampa Florida, 33614, United States

West Palm Beach Florida, 33407, United States

Atlanta Georgia, 30342, United States

Boise Idaho, 83702, United States

Idaho Falls Idaho, 83404, United States

Meridian Idaho, 83642, United States

Morton Grove Illinois, 60053, United States

Springfield Illinois, 62704, United States

Vernon Hills Illinois, 60061, United States

Indianapolis Indiana, 46202, United States

Cedar Rapids Iowa, 52401, United States

Des Moines Iowa, 50322, United States

Bowling Green Kentucky, 42102, United States

Lexington Kentucky, 40515, United States

Louisville Kentucky, 40202, United States

Baton Rouge Louisiana, 70808, United States

Shreverport Louisiana, 71103, United States

Slidell Louisiana, 70458, United States

Portland Maine, 04102, United States

Frederick Maryland, 21702, United States

Wheaton Maryland, 20902, United States

Boston Massachusetts, 02111, United States

Pittsfield Massachusetts, 01201, United States

Grand Rapids Michigan, 49546, United States

Kalamazoo Michigan, 49048, United States

Lansing Michigan, 48910, United States

Eagan Minnesota, 55121, United States

St Cloud Minnesota, 56303, United States

St. Louis Park Minnesota, 55426, United States

Flowood Mississippi, 39232, United States

Tupelo Mississippi, 38802, United States

Saint Louis Missouri, 63128, United States

Saint Louis Missouri, 63131, United States

Springfield Missouri, 65807, United States

St Louis Missouri, 63117, United States

St Louis Missouri, 63141, United States

Billings Montana, 59107, United States

Lincoln Nebraska, 68516, United States

Reno Nevada, 89502, United States

Dover New Hampshire, 03820, United States

Haddon Heights New Jersey, 08035, United States

New Brunswick New Jersey, 08903, United States

Passaic New Jersey, 07055, United States

Albuquerque New Mexico, 87131, United States

Albany New York, 12206, United States

Binghamton New York, 13905, United States

Great Neck New York, 11020, United States

New York New York, 10021, United States

Orchard Park New York, 14127, United States

Plainview New York, 11803, United States

Rochester New York, 14642, United States

Syracuse New York, 13210, United States

Asheville North Carolina, 28803, United States

Chapel Hill North Carolina, 27599, United States

Charlotte North Carolina, 28210, United States

Durham North Carolina, 27704, United States

Raleigh North Carolina, 27609, United States

Bismarck North Dakota, 58501, United States

Canton Ohio, 44718, United States

Cincinnati Ohio, 45219, United States

Cleveland Ohio, 44109, United States

Dayton Ohio, 45408, United States

Oklahoma City Oklahoma, 73103, United States

Oklahoma City Oklahoma, 73109, United States

Oklahoma City Oklahoma, 73112, United States

Tulsa Oklahoma, 74104, United States

Tulsa Oklahoma, 74135, United States

Eugene Oregon, 97401, United States

Medford Oregon, 97504, United States

Allentown Pennsylvania, 18103, United States

Bethlehem Pennsylvania, 18015, United States

Danville Pennsylvania, 17822, United States

Duncansville Pennsylvania, 16635, United States

Philadelphia Pennsylvania, 19152, United States

Pittsburgh Pennsylvania, 15261, United States

Willow Grove Pennsylvania, 19090, United States

Willow Grove Pennsylvania, 80045, United States

Wyomissing Pennsylvania, 19610, United States

Johnston Rhode Island, 02919, United States

Charleston South Carolina, 29406, United States

Columbia South Carolina, 29204, United States

Greenville South Carolina, 29601, United States

Hickory South Carolina, 28602, United States

Hixson Tennessee, 37343, United States

Jackson Tennessee, 38305, United States

Nashville Tennessee, 37203, United States

Amarillo Texas, 79124, United States

Austin Texas, 78705, United States

Austin Texas, 78749, United States

Dallas Texas, 75231, United States

Dallas Texas, 75231, United States

Houston Texas, 77074, United States

Mesquite Texas, 75150, United States

Burlington Vermont, 05401, United States

Chesapeake Virginia, 23320, United States

Norfolk Virginia, 23502, United States

Mountlake Terrace Washington, 98043, United States

Olympia Washington, 98502, United States

Seattle Washington, 98104, United States

Seattle Washington, 98195, United States

Spokane Washington, 99204, United States

Tacoma Washington, 98405, United States

Glendale Wisconsin, 53217, United States

Lacrosse Wisconsin, 54601, United States

Buenos Aires , C1015, Argentina

Buenos Aires , C1428, Argentina

Florencio Varela , B1878, Argentina

Rosario , S2000, Argentina

Hobart , 7000, Australia

Malvern , 3144, Australia

Shenton Park , 6008, Australia

Sydney , 2050, Australia

Woolloongabba , 4102, Australia

Hasselt , 3500, Belgium

Merksem , 2170, Belgium

Campinas , 13060, Brazil

Goiania , 74653, Brazil

Rio de Janeiro , 20551, Brazil

Calgary Alberta, T2V 1, Canada

Edmonton Alberta, T5H 3, Canada

Victoria British Columbia, V8V 3, Canada

Winnipeg Manitoba, R3A 1, Canada

St John's Newfoundland and Labrador, A1A 5, Canada

Burlington Ontario, L7R 1, Canada

Hamilton Ontario, L8N 2, Canada

Kitchener Ontario, N2M 5, Canada

London Ontario, N6A 4, Canada

Mississauga Ontario, L5M 2, Canada

Ottawa Ontario, K1H 1, Canada

Toronto Ontario, M5T 3, Canada

Montreal Quebec, H2L 1, Canada

Quebec City Quebec, G1V 3, Canada

Sainte-foy Quebec, G1W 4, Canada

Saskatoon Saskatchewan, S7N 0, Canada

Beijing , 10003, China

Beijing , 10004, China

Guangzhou , 51063, China

Hefei Anhui , 23002, China

Jinan , 25001, China

Shanghai , 20012, China

Shanghai , 20043, China

San Jose , 10103, Costa Rica

Hradec Kralove , 500 0, Czech Republic

Praha , 128 5, Czech Republic

Praha , 140 5, Czech Republic

Hellerup , 2900, Denmark

Helsinki , 00290, Finland

Jyväskylä , 40620, Finland

Amiens , 80054, France

Bordeaux , 33076, France

Boulogne-billancourt , 92104, France

Brest , 29609, France

Grenoble , 38042, France

Le Kremlin-bicetre , 94270, France

Lille , 59037, France

Lyon , 69437, France

Marseille , 13285, France

Montpellier , 34295, France

Nantes , 44035, France

Nice , 06202, France

Paris , 75181, France

Paris , 75679, France

Pierre Benite , 69495, France

Rennes , 35203, France

Rouen , 76031, France

St Priest En Jarez , 42277, France

Strasbourg , 67098, France

Toulouse , 31059, France

Aachen , 52064, Germany

Berlin , 10117, Germany

Dresden , 01067, Germany

Essen , 45239, Germany

Gommern , 39245, Germany

Herne , 44652, Germany

Hildesheim , 31134, Germany

Köln , 50924, Germany

München , 80335, Germany

München , 81541, Germany

Osnabrück , 49074, Germany

Sendenhorst , 48324, Germany

Wiesbaden , 65191, Germany

Wuerzburg , 97080, Germany

Hong Kong , 852, Hong Kong

Tuen Mun , 852, Hong Kong

Reykjavik , 108, Iceland

Ashkelon , 78306, Israel

Haifa , 31048, Israel

Haifa , 34354, Israel

Rishon Lezion , 70300, Israel

Brescia , 25123, Italy

Genova , 16132, Italy

Milano , 20157, Italy

Padova , 35128, Italy

Pavia , 27100, Italy

Pisa , 56100, Italy

Siena , 53100, Italy

Udine , 33100, Italy

Kaunas , 50009, Lithuania

Klaipeda , 92288, Lithuania

Panevezys , 35144, Lithuania

Siauliai , 76231, Lithuania

Vilnius , LT-08, Lithuania

Guadalajara , 44340, Mexico

Guadalajara , 44620, Mexico

Guadalajara , 45235, Mexico

Leon , 37000, Mexico

Mexico City , 06700, Mexico

Mexico City , 07760, Mexico

Mexico City , 14050, Mexico

Tijuana , 22320, Mexico

Nijmegen , 6525 , Netherlands

Levanger , 7600, Norway

Lillehammer , 2609, Norway

Panama City , 32400, Panama

Lima , 11, Peru

Lima , 13, Peru

Lisboa , 1349-, Portugal

Ponce , 00716, Puerto Rico

Moscow , 10520, Russian Federation

Moscow , 11552, Russian Federation

Moscow , 11704, Russian Federation

Ryazan , 39002, Russian Federation

St Petersburg , 19006, Russian Federation

St Petersburg , 19101, Russian Federation

Tula , 30005, Russian Federation

Belgrade , 11000, Serbia

Niska Banja , 18250, Serbia

Ljubljana , 1000, Slovenia

Maribor , 2000, Slovenia

Cape Town , 4001, South Africa

Cape Town , 7500, South Africa

Diepkloof , 1862, South Africa

Durban , 4001, South Africa

Pinelands , 7405, South Africa

Pretoria , 0002, South Africa

Radiokop , 2040, South Africa

Barakaldo , 48903, Spain

Barcelona , 08035, Spain

Madrid , 28046, Spain

Malaga , 29010, Spain

Pontevedra , 36001, Spain

Santiago de Compostela , 15706, Spain

Stockholm , 17176, Sweden

Umea , 90185, Sweden

Lausanne , 1011, Switzerland

Bangkok , 10330, Thailand

Bangkok , 10400, Thailand

Chiang Mai , 50200, Thailand

Basingstoke , RG24 , United Kingdom

Birmingham , B29 6, United Kingdom

Cannock , WS11 , United Kingdom

Derby , DE1 2, United Kingdom

Leeds , LS7 4, United Kingdom

London , SE1 9, United Kingdom

Manchester , M13 9, United Kingdom

Manchester , M41 5, United Kingdom

Middlesborough , TS4 3, United Kingdom

Newcastle Upon Tyne , NE1 4, United Kingdom

Oxford , OX3 7, United Kingdom

Southampton , SO16 , United Kingdom

Stoke-on-trent , ST6 7, United Kingdom

How clear is this clinincal trial information?

Study is for people with:

Multiple Myeloma

Phase:

Phase 3

Estimated Enrollment:

2067

Study ID:

NCT00720798

Recruitment Status:

Completed

Sponsor:


Hoffmann-La Roche

How clear is this clinincal trial information?

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