Multiple Myeloma Clinical Trial
An Extension Study of Tocilizumab (Myeloma Receptor Antibody [MRA]) in Patients Completing Treatment in Tocilizumab Core Studies
Summary
This single-arm study evaluated the long-term efficacy and safety of tocilizumab in participants who had completed treatment in the tocilizumab core studies (NCT00106522 [Roche protocol WA18062], NCT00106574 [Roche protocol WA18063], and NCT00109408 [Roche protocol WA17824]) of adults with rheumatoid arthritis. Participants received tocilizumab alone or in combination with standard anti-rheumatic treatment.
Eligibility Criteria
Inclusion Criteria:
Patients who have completed participation in 1 of the core studies in adult rheumatoid arthritis.
Exclusion Criteria:
Treatment with any investigational agent since the last administration of study drug in the core studies.
Treatment with iv gamma globulin, plasmapheresis, or prosorba column since the last administration of study drug in the core studies.
Treatment with an anti-TNF or anti-IL1 agent, a T-cell co-stimulation modulator, or any biologic since the last administration of study drug in the core studies.
Immunization with a live/attenuated vaccine since the last administration of study drug in the core studies.
Previous treatment with any cell-depleting therapies, including investigational agents.
Parenteral, intramuscular, or intra-articular corticosteroids within 6 weeks prior to baseline in this study.
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There are 290 Locations for this study
Birmingham Alabama, 35294, United States
Huntsville Alabama, 35801, United States
Mesa Arizona, 85208, United States
Paradise Valley Arizona, 85253, United States
Peoria Arizona, 85381, United States
Scottsdale Arizona, 85251, United States
Scottsdale Arizona, 85258, United States
Tucson Arizona, 85723, United States
Tucson Arizona, 85724, United States
Little Rock Arkansas, 72205, United States
Anaheim California, 92801, United States
Long Beach California, 90806, United States
Long Beach California, 90808, United States
Los Angeles California, 90045, United States
Los Angeles California, 90095, United States
Palm Desert California, 92260, United States
Palm Springs California, 92262, United States
Palo Alto California, 94304, United States
San Diego California, 92101, United States
San Diego California, 92108, United States
San Jose California, 95126, United States
San Leandro California, 94578, United States
Santa Maria California, 93454, United States
Torrance California, 90505, United States
Upland California, 91786, United States
Colorado Springs Colorado, 80910, United States
Newark Delaware, 19713, United States
Aventura Florida, 33180, United States
Delray Beach Florida, 33484, United States
Fort Lauderdale Florida, 33334, United States
Palm Habor Florida, 34684, United States
Palm Harbor Florida, 34684, United States
Sarasota Florida, 34239, United States
Tampa Florida, 33609, United States
Tampa Florida, 33614, United States
West Palm Beach Florida, 33407, United States
Atlanta Georgia, 30342, United States
Boise Idaho, 83702, United States
Idaho Falls Idaho, 83404, United States
Meridian Idaho, 83642, United States
Morton Grove Illinois, 60053, United States
Springfield Illinois, 62704, United States
Vernon Hills Illinois, 60061, United States
Indianapolis Indiana, 46202, United States
Cedar Rapids Iowa, 52401, United States
Des Moines Iowa, 50322, United States
Bowling Green Kentucky, 42102, United States
Lexington Kentucky, 40515, United States
Louisville Kentucky, 40202, United States
Baton Rouge Louisiana, 70808, United States
Shreverport Louisiana, 71103, United States
Slidell Louisiana, 70458, United States
Portland Maine, 04102, United States
Frederick Maryland, 21702, United States
Wheaton Maryland, 20902, United States
Boston Massachusetts, 02111, United States
Pittsfield Massachusetts, 01201, United States
Grand Rapids Michigan, 49546, United States
Kalamazoo Michigan, 49048, United States
Lansing Michigan, 48910, United States
Eagan Minnesota, 55121, United States
St Cloud Minnesota, 56303, United States
St. Louis Park Minnesota, 55426, United States
Flowood Mississippi, 39232, United States
Tupelo Mississippi, 38802, United States
Saint Louis Missouri, 63128, United States
Saint Louis Missouri, 63131, United States
Springfield Missouri, 65807, United States
St Louis Missouri, 63117, United States
St Louis Missouri, 63141, United States
Billings Montana, 59107, United States
Lincoln Nebraska, 68516, United States
Reno Nevada, 89502, United States
Dover New Hampshire, 03820, United States
Haddon Heights New Jersey, 08035, United States
New Brunswick New Jersey, 08903, United States
Passaic New Jersey, 07055, United States
Albuquerque New Mexico, 87131, United States
Albany New York, 12206, United States
Binghamton New York, 13905, United States
Great Neck New York, 11020, United States
New York New York, 10021, United States
Orchard Park New York, 14127, United States
Plainview New York, 11803, United States
Rochester New York, 14642, United States
Syracuse New York, 13210, United States
Asheville North Carolina, 28803, United States
Chapel Hill North Carolina, 27599, United States
Charlotte North Carolina, 28210, United States
Durham North Carolina, 27704, United States
Raleigh North Carolina, 27609, United States
Bismarck North Dakota, 58501, United States
Canton Ohio, 44718, United States
Cincinnati Ohio, 45219, United States
Cleveland Ohio, 44109, United States
Dayton Ohio, 45408, United States
Oklahoma City Oklahoma, 73103, United States
Oklahoma City Oklahoma, 73109, United States
Oklahoma City Oklahoma, 73112, United States
Tulsa Oklahoma, 74104, United States
Tulsa Oklahoma, 74135, United States
Eugene Oregon, 97401, United States
Medford Oregon, 97504, United States
Allentown Pennsylvania, 18103, United States
Bethlehem Pennsylvania, 18015, United States
Danville Pennsylvania, 17822, United States
Duncansville Pennsylvania, 16635, United States
Philadelphia Pennsylvania, 19152, United States
Pittsburgh Pennsylvania, 15261, United States
Willow Grove Pennsylvania, 19090, United States
Willow Grove Pennsylvania, 80045, United States
Wyomissing Pennsylvania, 19610, United States
Johnston Rhode Island, 02919, United States
Charleston South Carolina, 29406, United States
Columbia South Carolina, 29204, United States
Greenville South Carolina, 29601, United States
Hickory South Carolina, 28602, United States
Hixson Tennessee, 37343, United States
Jackson Tennessee, 38305, United States
Nashville Tennessee, 37203, United States
Amarillo Texas, 79124, United States
Austin Texas, 78705, United States
Austin Texas, 78749, United States
Dallas Texas, 75231, United States
Dallas Texas, 75231, United States
Houston Texas, 77074, United States
Mesquite Texas, 75150, United States
Burlington Vermont, 05401, United States
Chesapeake Virginia, 23320, United States
Norfolk Virginia, 23502, United States
Mountlake Terrace Washington, 98043, United States
Olympia Washington, 98502, United States
Seattle Washington, 98104, United States
Seattle Washington, 98195, United States
Spokane Washington, 99204, United States
Tacoma Washington, 98405, United States
Glendale Wisconsin, 53217, United States
Lacrosse Wisconsin, 54601, United States
Buenos Aires , C1015, Argentina
Buenos Aires , C1428, Argentina
Florencio Varela , B1878, Argentina
Rosario , S2000, Argentina
Hobart , 7000, Australia
Malvern , 3144, Australia
Shenton Park , 6008, Australia
Sydney , 2050, Australia
Woolloongabba , 4102, Australia
Hasselt , 3500, Belgium
Merksem , 2170, Belgium
Campinas , 13060, Brazil
Goiania , 74653, Brazil
Rio de Janeiro , 20551, Brazil
Calgary Alberta, T2V 1, Canada
Edmonton Alberta, T5H 3, Canada
Victoria British Columbia, V8V 3, Canada
Winnipeg Manitoba, R3A 1, Canada
St John's Newfoundland and Labrador, A1A 5, Canada
Burlington Ontario, L7R 1, Canada
Hamilton Ontario, L8N 2, Canada
Kitchener Ontario, N2M 5, Canada
London Ontario, N6A 4, Canada
Mississauga Ontario, L5M 2, Canada
Ottawa Ontario, K1H 1, Canada
Toronto Ontario, M5T 3, Canada
Montreal Quebec, H2L 1, Canada
Quebec City Quebec, G1V 3, Canada
Sainte-foy Quebec, G1W 4, Canada
Saskatoon Saskatchewan, S7N 0, Canada
Beijing , 10003, China
Beijing , 10004, China
Guangzhou , 51063, China
Hefei Anhui , 23002, China
Jinan , 25001, China
Shanghai , 20012, China
Shanghai , 20043, China
San Jose , 10103, Costa Rica
Hradec Kralove , 500 0, Czech Republic
Praha , 128 5, Czech Republic
Praha , 140 5, Czech Republic
Hellerup , 2900, Denmark
Helsinki , 00290, Finland
Jyväskylä , 40620, Finland
Amiens , 80054, France
Bordeaux , 33076, France
Boulogne-billancourt , 92104, France
Brest , 29609, France
Grenoble , 38042, France
Le Kremlin-bicetre , 94270, France
Lille , 59037, France
Lyon , 69437, France
Marseille , 13285, France
Montpellier , 34295, France
Nantes , 44035, France
Nice , 06202, France
Paris , 75181, France
Paris , 75679, France
Pierre Benite , 69495, France
Rennes , 35203, France
Rouen , 76031, France
St Priest En Jarez , 42277, France
Strasbourg , 67098, France
Toulouse , 31059, France
Aachen , 52064, Germany
Berlin , 10117, Germany
Dresden , 01067, Germany
Essen , 45239, Germany
Gommern , 39245, Germany
Herne , 44652, Germany
Hildesheim , 31134, Germany
Köln , 50924, Germany
München , 80335, Germany
München , 81541, Germany
Osnabrück , 49074, Germany
Sendenhorst , 48324, Germany
Wiesbaden , 65191, Germany
Wuerzburg , 97080, Germany
Hong Kong , 852, Hong Kong
Tuen Mun , 852, Hong Kong
Reykjavik , 108, Iceland
Ashkelon , 78306, Israel
Haifa , 31048, Israel
Haifa , 34354, Israel
Rishon Lezion , 70300, Israel
Brescia , 25123, Italy
Genova , 16132, Italy
Milano , 20157, Italy
Padova , 35128, Italy
Pavia , 27100, Italy
Pisa , 56100, Italy
Siena , 53100, Italy
Udine , 33100, Italy
Kaunas , 50009, Lithuania
Klaipeda , 92288, Lithuania
Panevezys , 35144, Lithuania
Siauliai , 76231, Lithuania
Vilnius , LT-08, Lithuania
Guadalajara , 44340, Mexico
Guadalajara , 44620, Mexico
Guadalajara , 45235, Mexico
Leon , 37000, Mexico
Mexico City , 06700, Mexico
Mexico City , 07760, Mexico
Mexico City , 14050, Mexico
Tijuana , 22320, Mexico
Nijmegen , 6525 , Netherlands
Levanger , 7600, Norway
Lillehammer , 2609, Norway
Panama City , 32400, Panama
Lima , 11, Peru
Lima , 13, Peru
Lisboa , 1349-, Portugal
Ponce , 00716, Puerto Rico
Moscow , 10520, Russian Federation
Moscow , 11552, Russian Federation
Moscow , 11704, Russian Federation
Ryazan , 39002, Russian Federation
St Petersburg , 19006, Russian Federation
St Petersburg , 19101, Russian Federation
Tula , 30005, Russian Federation
Belgrade , 11000, Serbia
Niska Banja , 18250, Serbia
Ljubljana , 1000, Slovenia
Maribor , 2000, Slovenia
Cape Town , 4001, South Africa
Cape Town , 7500, South Africa
Diepkloof , 1862, South Africa
Durban , 4001, South Africa
Pinelands , 7405, South Africa
Pretoria , 0002, South Africa
Radiokop , 2040, South Africa
Barakaldo , 48903, Spain
Barcelona , 08035, Spain
Madrid , 28046, Spain
Malaga , 29010, Spain
Pontevedra , 36001, Spain
Santiago de Compostela , 15706, Spain
Stockholm , 17176, Sweden
Umea , 90185, Sweden
Lausanne , 1011, Switzerland
Bangkok , 10330, Thailand
Bangkok , 10400, Thailand
Chiang Mai , 50200, Thailand
Basingstoke , RG24 , United Kingdom
Birmingham , B29 6, United Kingdom
Cannock , WS11 , United Kingdom
Derby , DE1 2, United Kingdom
Leeds , LS7 4, United Kingdom
London , SE1 9, United Kingdom
Manchester , M13 9, United Kingdom
Manchester , M41 5, United Kingdom
Middlesborough , TS4 3, United Kingdom
Newcastle Upon Tyne , NE1 4, United Kingdom
Oxford , OX3 7, United Kingdom
Southampton , SO16 , United Kingdom
Stoke-on-trent , ST6 7, United Kingdom
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