Study of BMS-986393 a GPRC5D-directed CAR T Cell Therapy in Adult Participants With Relapsed or Refractory Multiple Myeloma Summary The purpose of this study is to evaluate the effectiveness and safety of BMS-986393 in participants with relapse d or refractory multiple myeloma .
View Eligibility Criteria Eligibility Criteria Inclusion Criteria Documented diagnosis of multiple Mmyeloma (MM) as per International Myeloma Working Group (IMWG) criteria. Received at least 4 classes of MM treatment [including immunomodulatory drug (IMiD), proteasome inhibitor (PI), anti CD38 mAb, and anti-B cell maturation antigen (BCMA) therapy], and at least 3 prior lines of therapy (LOT). Documented disease progression during or after their last anti-myeloma regimen as per IMWG. Participants must have measurable disease during screening. Have measurable disease during screening. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. Exclusion Criteria Active or history of central nervous system involvement with MM. Active systemic fungal, bacterial, viral, or other infection despite appropriate anti-infective treatment at the time of leukapheresis. Received any prior therapy directed at G protein-coupled receptor class C, group 5, member D (GPRC5D) or has received other prior treatment for MM without the required washout prior to leukapheresis. Other protocol-defined Inclusion/Exclusion criteria apply.
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There are 36 Locations for this study
Local Institution - 0001 Birmingham Alabama, 35294, United States
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Local Institution - 0025 Gilbert Arizona, 85234, United States
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Local Institution - 0037 Little Rock Arkansas, 72205, United States
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UCLA Hematology/Oncology - Westwood (Building 200 Suite 214) Los Angeles California, 90095, United States
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Local Institution - 0018 San Francisco California, 94143, United States
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Colorado Blood Cancer Institute Denver Colorado, 80218, United States
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Local Institution - 0045 Miami Florida, 33176, United States
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Local Institution - 0029 Tampa Florida, 33612, United States
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Local Institution - 0009 Atlanta Georgia, 30322, United States
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Local Institution - 0004 Atlanta Georgia, 30342, United States
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Local Institution - 0005 Chicago Illinois, 60611, United States
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Local Institution - 0056 Chicago Illinois, 60637, United States
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University of Iowa Iowa City Iowa, 52242, United States
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Local Institution - 0016 Westwood Kansas, 66205, United States
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Local Institution - 0026 Saint Matthews Kentucky, 40207, United States
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Local Institution - 0039 Boston Massachusetts, 02114, United States
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Local Institution - 0036 Boston Massachusetts, 02215, United States
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Local Institution - 0033 Rochester Minnesota, 55905, United States
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Washington University School of Medicine Saint Louis Missouri, 63110, United States
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Local Institution - 0034 New Brunswick New Jersey, 08903, United States
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Local Institution - 0046 Buffalo New York, 14263, United States
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Local Institution - 0002 New York New York, 10029, United States
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Local Institution - 0003 New York New York, 10065, United States
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Local Institution - 0031 Chapel Hill North Carolina, 27599, United States
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Local Institution - 0054 Cincinnati Ohio, 45242, United States
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Local Institution - 0032 Columbus Ohio, 43210, United States
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Local Institution - 0038 Portland Oregon, 97239, United States
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Local Institution - 0043 Nashville Tennessee, 37232, United States
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Local Institution - 0035 Dallas Texas, 75390, United States
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University of Texas MD Anderson Cancer Center Houston Texas, 77030, United States
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Local Institution - 0055 San Antonio Texas, 78229, United States
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Local Institution - 0050 Salt Lake City Utah, 84143, United States
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Local Institution - 0011 Seattle Washington, 98109, United States
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University Hospital and UW Health Clinics Madison Wisconsin, 53792, United States
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Local Institution - 0020 Calgary Alberta, T2N 4, Canada
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Local Institution - 0021 Montréal Quebec, H4A 3, Canada
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