A Study of Opportunistic Salpingectomy to Prevent Ovarian Cancer

Inclusion Criteria:

Part I

Age ≥45 years
Scheduled visit with a nongynecologic surgeon
Female or assigned female at birth

Part II

Age ≥45 years
At least one in situ fallopian tube
No desire or plan to have children in the future

Average risk of developing ovarian cancer

° Note: Average risk patients are defined as patients with no known genetic risk factor for developing ovarian cancer. Patients who, after obtaining family history, are suspected to have a hereditary ovarian cancer syndrome but have not yet been tested, will be referred for genetic evaluation.

Planned nongynecologic, intraabdominal, or pelvic surgery
Deemed to be a suitable candidate by gynecologic surgeon and primary nongynecologic surgeon (for example, on the basis of surgical history and current malignancy status)
Approved and signed informed consent

Exclusion Criteria:

Part I

Not fluent in English

° If there is a non-english speaking participant who is a strong candidate and meets all other criteria for Part 2, they are able to go directly onto Part 2 without completing Part 1. (Please see additional details in section 4.1 and 7.0.)

Known inherited ovarian cancer susceptibility

Part II

Personal history of a gynecologic malignancy
Carrier of a hereditary breast or ovarian cancer variant (e.g., BRCA1, BRCA2, BRIP1, PALB2, RAD51C, RAD51D, MLH1, MSH2, MSH6, PMS2)
Suspicious ovarian, fallopian tube, or uterine lesion on preoperative imaging
Previous bilateral salpingectomy or bilateral salpingo-oophorectomy
Current pregnancy
Emergent procedure or emergency procedure that has to be completed within 24 hours where clinical consent occurs in the inpatient setting or where the patient's immediate well-being is in danger or condition may be life threatening
Primary surgeon anticipates that OS will add significant time (>30-40min) to the planned procedure.
Inability to access the pelvis (ex., patient prone/lateral position) during the planned procedure.
Known history of pelvic fibrosis or significant adhesions.
Procedures with palliative intent only