Trametinib in Treating Patients With Progressive Metastatic Hormone-Resistant Prostate Cancer

Inclusion Criteria:

Willing and able to give informed consent
Histologically confirmed prostate cancer (not exclusive of adenocarcinoma)
mCRPC that has progressed on at least 1 therapy progression (defined as Prostate Cancer Working Group 2 [PCWG2] or at investigators' discretion) approved for treatment of mCRPC, one of which must include abiraterone acetate and/or enzalutamide
Metastatic tumor that has been biopsied
Eastern Cooperative Oncology Group (ECOG) performance status of 0-2
Willing to undergo biopsy of a metastatic lesion at the time of progression
Patients must have ongoing therapy to maintain serum testosterone < 50 ng/dL
Absolute neutrophil count > 1,500/uL during screening evaluation
Platelet count > 100,000/uL during screening evaluation
Hemoglobin > 9 g/dL during screening evaluation
Total bilirubin within the reference range during screening evaluation
Alanine aminotransferase (ALT) within the reference range during screening evaluation
Aspartate aminotransferase (AST) within the reference range during screening evaluation
Creatinine < (1.5 mg/dL) during screening evaluation (> 1.5 is allowed if epidermal growth factor receptor [EGFR] > 45 mL/min/1.73 m^2)
International normalized ratio (INR) < 1.3 (or < 3 if on warfarin or other anticoagulants) during screening evaluation
Left ventricular ejection fraction (LVEF) >= 45% as measured by echocardiogram during screening evaluation
Electrocardiogram (EKG) without clinically significant abnormality

Exclusion Criteria:

A history of retinal vein occlusion (RVO) or risks factors for RVO
A history of retinal pigment epithelial detachment (RPED) or risk factors for RPED
Clinically significant abnormality on ophthalmologic examination during screening evaluation

Clinically significant cardiovascular disease including:

LVEF < 45% measured by echocardiogram
History of acute coronary syndromes (including myocardial infarction and unstable angina), coronary angioplasty, or stenting within 6 months
Uncontrolled angina within 3 months
New York Heart Association (NYHA) class III or IV congestive heart failure
Clinically significant abnormality on EKG
History of clinically significant ventricular arrhythmias (e.g., ventricular tachycardia, ventricular fibrillation, torsades de pointes)
Patients with intra-cardiac defibrillators or permanent pacemakers
Presence of a comorbid disease or medical condition that would impair the ability of the patient to receive or comply with the study protocol
History of interstitial lung disease or pneumonitis
Use of any medication or herbal products that may have hormonal anti-prostate cancer activity and/or are known to modulate PSA levels (e.g., saw palmetto) or systemic corticosteroids greater than the equivalent of 10 mg of prednisone per day within 4 weeks of enrollment
Prior use of trametinib or other mitogen activated protein kinase (MAPK) inhibitor in any context
Known or suspected brain metastasis or active leptomeningeal disease or spinal cord compression
Gastrointestinal disorder affecting absorption (e.g., gastrectomy, active peptic ulcer disease within last 3 months, inflammatory bowel disease)
Any major surgery, extensive radiotherapy, chemotherapy with delayed toxicity, biologic therapy, or immunotherapy within 30 days of enrollment and/or daily or weekly chemotherapy without the potential for delayed toxicity within 14 days of enrollment
Hospitalization within 30 days of enrollment for cancer related events
History of another malignancy within the previous 5 years other than curatively treated non-melanoma skin cancer
Use of an investigational agent within 4 weeks of enrollment
Use of any medications known to affect the serum androgen level
Any condition or reason that, in the opinion of the investigator, interferes with the ability of the patient to participate in the trial, which places the patient at undue risk, or complicates the interpretation of safety data